Immunohistochemistry: 2-4 μg/mL, peptide-ELISA: 1:16000, Western Blot: 0.1-0.3 μg/mL
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Description
PPP4C Polyclonal Antibody. Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interpha
Immunogen
n/a
Other Names
PPP4C; protein phosphatase 4 (formerly X), catalytic subunit; PP4; PPH3; PPX; Protein phosphatase 4, catalytic subunit