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Description
TOP3A Polyclonal Antibody. DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA by transiently breaking and rejoining DNA strands. Although DNA topoisomerase I (Topo I) and Topo II relax both positive and negative supercoils, Topo III relaxes only negative supercoils. Topo IIIα exists as a long and a short isoform, which are produced by alternative splicing. Topo IIIα, which localizes to the nucleolus, is constitutively expressed and remains at high levels throughout the cell cycle in HL-60 cells. Topo IIIβ exists as three isoforms,β-1,β -2 and β-3, also produced by alternative splicing. Topo IIIβ-1 is expressed in testis, heart, and skeletal muscle, whereas Topo III&beta
Immunogen
n/a
Other Names
DNA topoisomerase 3-alpha; DNA topoisomerase III alpha; TOP3A; TOP3