bovine, canine, human, mouse, nonhuman primate, rat
Isotype
n/a
Format
purified
Size
100 μL
Concentration
n/a
Applications
Immunocytochemistry: 1:10-1:2000, Immunofluorescence: 1:10-1:2000, Western Blot: 1:250-1:1000
Reviews / Ratings
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Description
HTRA1 Polyclonal Antibody. HtrA1, a 51KDa protein, is a member of highly conserved mammalian HtrA serine protease family. It is a human homolog of bacterial HtrA and consists of a secretory signal sequence, an IGFBP-binding domain and a Kazal-type serine-protease inhibitor domain at the N-terminus and a highly conserved trypsin-like serine/protease domain and a PDZ domain at the C-terminus. It plays a major role in the regulation of cell growth. HtrA1 inhibits signaling mediated by TGF-beta family members and regulates many physiological processes. HtrA1 is up-regulated in placenta during pregnancy and plays an important role in implantation and placental physiology. It regulates the availability of IGFs by cleaving IGF-binding proteins. It