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Description
NMDAR1 Monoclonal Antibody (54.1). N-methyl-D-aspartate (NMDA) type receptors are glutamate-gated ion channels that possess high-calcium permeability and voltage-dependent sensitivity to magnesium, and play a central role in brain function and disease. Activation of NMDA receptors, in the presence of NMDA, glutamate, and glycine, leads to elevations in synaptic calcium levels, initiating a series of calcium-dependent signaling events including activation of nitric oxide synthase, stimulation of calcium/calmodulin-dependent protein kinase, and MAP kinase cascades. Through these signal transduction pathways, NMDA receptors mediate synaptic plasticity, synaptogenesis, excitotoxicity, and memory acquisition and learning. NMDA receptors are comp