Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) (Extracellular Domain), (AA 52-212) (Active) protein (Fc Tag)
Description
TRAIL-R2 (DR5, CD262) is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB.