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Description
PICK1 Polyclonal Antibody. PSD-95/DLG/ZO-1 (PDZ) domain-containing proteins play a central role in synaptic membrane protein localization. The protein interacting with protein kinase C (PICK1) is a synaptic PDZ domain protein that also contains a coiled-coil and acidic domain. Studies indicate that PICK1 functions as a targeting and transport protein and has been shown to interact with protein kinase C alpha (PKC alpha), AMPA-type glutamate receptors, and several other membrane receptors via its PDZ domain. The interaction of PICK1 with PKC alpha is highly dependent on the activation of the kinase. It appears that PICK1 directs the activated form of PKC alpha to membrane anchored GluR2. Once phosphorylated by PKC alpha, GluR2 is released fr
Immunogen
n/a
Other Names
PRKCA-binding protein; Protein kinase C-alpha binding protein; Protein interacting with C kinase 1; PICK1