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| Antigenic Specificity | PIF1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | mouse |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 μL |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Paraffin): 1:300 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | PIF1 Polyclonal Antibody. PIF1 is a single-stranded (ss) DNA-dependent ATPase as well as a DNA helicase that unwinds DNA in a 5' to 3' direction with respect to the DNA strand on which it binds first. This protein is critical to DNA replication and telomere length maintenance in Saccharomyces cerevisiae. The PIF1 gene is highly conserved from yeast to humans. Mutations in the gene that encodes for PIF1 cause all telomeres to lengthen, suggesting that the PIF1 functions as a catalytic inhibitor of both new telomere formation and telomere elongation. Human PIF1 preferentially binds telomeric DNA where it inhibits telomerase activity. PIF1 specifically counteracts the RecQ homolog Sgs1 helicase activity, and degradation of PIF1 is mediated by |
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| Immunogen | n/a |
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| Other Names | ATP-dependent DNA helicase PIF1, DNA repair and recombination helicase PIF-1, PIF1/RRM3 DNA helicase-like protein, C15orf20 |
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| Gene, Accession # | Entrez: 208084; Uniprot: Q80SX8 |
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| Catalog # | PA5-72989 |
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| Price | |
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| Order / More Info | PIF1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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