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Description
PIGA Polyclonal Antibody. This gene encodes a protein required for synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the biosynthetic pathway of GPI anchor. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. Paroxysmal nocturnal hemoglobinuria, an acquired hematologic disorder, has been shown to result from mutations in this gene. Alternate splice variants have been characterized.
Immunogen
n/a
Other Names
GPI3, PIG-A, GLCNAC-PI synthesis protein, GPI anchor biosynthesis, class A GlcNAc-inositol phospholipid assembly protein, phosphatidylinositol N-acetylglucosaminyltransferase subunit A, phosphatidylinositol-glycan biosynthesis, class A protein