bovine, canine, equine, guinea pig, human, mouse, rabbit, rat, zebrafish
Isotype
n/a
Format
purified
Size
100 μl
Concentration
n/a
Applications
Immunohistochemistry (Paraffin): 4-8 μg/mL, Western Blot: 0.2-1 μg/mL
Reviews / Ratings
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Description
Slap Polyclonal Antibody. SLAP also known as Src-like-adapter protein 1 is a 276 amino acid containing adapter protein, functioning as a negative regulator of T-cell receptor (TCR) signaling. SLAP belonging to the SRC family of cytoplasmic tyrosine kinases contains a SH2 domain and a SH3 domain. This cytoplasmic protein colocalizes with endosomes and is known to inhibit T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. It acts as a negative regulator of positive selection and mitosis of T-cells. SLAP may act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. Expression of SLAP is weak in heart, adult brain, placenta, liver, skeletal muscle, kid