A potent S1P1 receptor agonist (EC50 = 9 pM); induces internalization and polyubiquitination of S1P1 in a dose-dependent manner; induces dose-dependent lymphopenia in mice (EC50 = 0.03 mg/kg); reduces S1P1-EGFP expression ex vivo on lymphocytes in the isolated lymph node of Edg1eGFP/eGFP mice; inhibits MSS rechallenge-induced enlargement of B cell-rich TLTs and reduces neutrophil accumulation in the airways of a mouse model of experimental hypersensitivity pneumonitis,