A small molecule CD4 mimetic; inhibits gp120 and CD4 interaction, preventing HIV from entering cells; inhibits infection of PM1/CCR5 cells from lab isolates of the HIV-1 strains IIIB (X4, Sub B) and 89.6 (dual, Sub B) (IC50s = 23 and 41 μM, respectively); inhibits infection of PM1/CCR5 cells from clinical isolates of the fTOI (R5, Sub B) and KYAG strains (R5, Sub B) (IC50s = 16 and 51 μM, respectively); inhibits HIV-1 infection of TZM-bl cells (IC50 = 8.4 μM); reduces viability of mock-infected PM1/CCR5 cells with cytotoxic concentration (CC50) values of 260 μM
Size
25 mg
Concentration
n/a
Applications
n/a
Other Names
YYA021 CD-4 Human Immunodeficiency Virus envelope glycoprotein YYA21