An inhibitor of human reticulocyte 15-LO-1 (IC50 = 200 nM) with >250-fold selectivity over the related enzymes 5-LO, platelet 12-LO, 15-LO-2, ovine COX-1, and human COX-2; protects against oxidative glutamate toxicity in mouse neuronal HT-22 cells and significantly reduces infarct size in an in vivo mouse model for ischemic stroke