A cell-permeable pyrimido-pyrrolo-quinoxalinedione that reversibly inhibits CFTR chloride channels (IC50 = 90 nM); reduces the size and number of renal cysts in a neonatal kidney organ culture model of polycystic kidney disease; increases VEGF-A production in cultured airway epithelial NCI-H292 cells
Size
10 mg
Concentration
n/a
Applications
n/a
Other Names
CFTR Inhibitor IV|Cystic Fibrosis Transmembrane Conductance Regulator Inhibitor IV