Purity ≥98% by HPLC. MW: 580.13. CEP-37440 is a potent and selective dual FAK/ALK inhibitor with IC50 s of 2.3 nM (FAK) and 120 nM (ALK cellular IC50 in 75% human plasma). The inhibition leads to disruption of ALK- and FAK-mediated signal transduction pathways and eventually inhibits tumor cell growth in ALK- and FAK-overexpressing tumor cells. It blocks the proliferation of inflammatory and triple-negative breast cancer cell lines but not normal breast epithelial cells.