A TAM family kinase inhibitor (IC50s = 2.9, 37, and 48 nM for Mer, Axl, and Tyro3, respectively); antiproliferative against ALL cells (IC50s = 0.5 and 1.2 μM for 697 and Jurkat cell lines, respectively); inhibits Mer phosphorylation (IC50s = 141 and 193 nM in 697 and Jurkat cell lines, respectively); decreases tumor burden by 47.8% relative to controls in human MYC transgenic zebrafish (4 μM); delays leukemia onset, reduces CNS infiltration, and prolongs survival of mice implanted with patient-derived Mer-expressing ALL primary cells (10 mg/kg)
Size
1 mg
Concentration
n/a
Applications
n/a
Other Names
UNC-569 RTK tyro-3 anti-proliferative erk-1 2 erk1 erk2 central nervous system