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Description
Rabbit IgG polyclonal Picoband? antibody for Elafin(PI3) detection. Tested with WB, IHC-P, ELISA in Human. No cross reactivity with other proteins. Elafin, also known as peptidase inhibitor 3 or skin-derived antileukoprotease (SKALP), is a protein that in humans is encoded by the PI3 gene. This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria, and fungal pathogens. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. And this gene belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines.
Immunogen
E. coli-derived human Elafin/Skalp recombinant protein (Position: A61-Q117).