WM209 is a metastatic human melanoma cell line that forms flat tight colonies in culture medium. This cell line contains a G12A mutation at position 12 of the N-RAS gene. This cell line also expresses PTEN loss of function including homozygous deletion and is wild type for BRAF, c-KIT and CDK4. WM209 cells produce xenograft tumors when injected into immunocompromised mice.
Size
1 mL
Concentration
10.0 million cells/ml
Applications
The key applications of these cell lines include genetic studies, xenograft production, drug testing, and drug target discovery. These cell line models can be used in various biological assays, and for identifying critical target genes, and cell signaling pathways.
Other Names
Human Melanoma, patient derived tumor, tumor models, skin cancer, xenograft