IL-33 belongs to the IL-1 family and is closely related in structure to IL-18 and IL-1β. IL-33, IL-1β, and IL-18 are synthesized as biologically inactive precursor and are cleaved by the enzyme caspase-1 to be secreted as active mature forms. IL-33 stimulates target cells by binding to the IL-1R/TLR superfamily member ST2 and subsequently activates NF-κB and MAPK pathways via identical signaling events to those observed for IL-1b. In addition, IL-33 is a nuclear factor (NF-HEV) abundantly expressed in high endothelial venules from lymphoid organs that associates with chromatin and exhibits transcriptional regulatory properties. IL-33 plays a role in allergic disease, including allergic rhinitis and chronic rhinosinusitus and is elevated in humans and mouse models of atopic dermatitis.
Size
100 μg
Concentration
n/a
Applications
BA
Other Names
Interleukin-33, IL-33, Interleukin-1 Family, Member 11 (IL-1F11), Nuclear Factor From High Endothelial Venules (NF-HEV)