(Arg6) IGF-II, recombinant protein (Receptor Grade)
Description
Product Specifications:Description:[Arg6]Insulin-like Growth Factor-II [R6]IGF-II) is an analog of human IGF-II, which has an Arg substitution in place of Glu at position 6 of the IGF-II amino acid sequence. It is therefore the IGF-II equivalent of [Arg3]IGF-I. [Arg6]IGF-II exhibits reduced affinity for IGF binding proteins (IGFBPs) compared with IGF-II and has a slightly greater affinity than Des(1-6)IGF-II for the Type 2 IGF receptor.
Francis G. L. et al. (1993) Biochem. J., 293, 713-719 Source:Produced recombinantly in E.coli Purity:> 95 % (by HPLC and N-terminal sequence analysis) Molecular Weight:7496 daltons - confirmed by Mass Spectrometry N-terminal sequence analysis:7 residues > 95 % single sequence Biological Activity: Type 2 IGF receptor binding assay: ED50 1000 ng/ml Stimulation of protein synthesis in rat L6 myoblasts: ED50 < 100 ng/mlEndotoxin: < 0.1 EU/μgState and Appearance: Lyophilized white powder. Dried from 0.1 M acetic acid and stored under dry nitrogen at a slight vacuum (-25 kPa) Storage/Stability:At least 2 years at 2 - 4°C (lyophilized) This is a GroPep specification. ibt is authorized distributor of GroPep.