(Arg3) IGF-I, recombinant protein (Receptor Grade)
Description
Description:Human [Arg ]Insulin-like Growth Factor-I ([Arg ]IGF-I) is a 70 amino acid analog of human IGF-I comprising the complete human IGF-I sequence with the substitution of an Arg for the Glu at position 3 (hence [Arg ]). GroPep scientists have engineered this analog with the express purpose of increasing biological activity. Human [Arg ]IGF-I is significantly more potent than human IGF-I in vitro and in vivo. It is offered to customers who prefer a full length IGF rather than the truncated human Des(1-3)IGF-I which has similar properties. The enhanced potency is due to the markedly decreased binding of human [Arg ]IGF-I to all IGF binding proteins which normally inhibit the biological actions of IGFs. Human [Arg ]IGF-I is covered by the following patents assigned to GroPep: US patent 5,164,370