Purity > 90% as determined by SDS-PAGE. MW: 34.2kDa. Full Length of Mature Protein: 25-184aa. N-terminal 6xHis-SUMO-tagged. Rattus norvegicus (Rat). Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner (By similarity). Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed.
Size
100ug
Concentration
n/a
Applications
RUO
Other Names
Cysteine knot superfamily 1, BMP antagonist 1; Down-regulated in Mos-transformed cells protein