Soluble Cluster of Differentiation 14 (sCD14) (Soluble) (Active) protein
Description
CD14 is a cell surface anchored glycoprotein that is expressed predominantly by monocytes and tissue macrophages. CD14 associates with MD-2 (LY-96) and TLR4 to form a receptor complex, which signals specifically in response to bacterial lipopolysaccharide (LPS) binding. The CD14/MD-2/TLR4 receptor complex signals via MyD88, TIRAP, and TRAF6, and ultimately activates NF-kappa-beta. CD14 also exists in a soluble form, designated as sCD14, which is capable of specifically binding LPS in the extracellular space. Alternative Names: sCD-14 protein, sCD-14, sCD-14 protein, sCD 14 protein, sCD14, soluble CD14 protein, sCD 14