A selective Ras inhibitor that blocks H-Ras GTP binding to c-Raf-1 (Ki = 149 μM); inhibits both anchorage-dependent and -independent growth and induces apoptosis of H-RasG12V-transformed NIH 3T3 cells (IC50 = 1.4-2 μM)
Size
100 mg
Concentration
n/a
Applications
n/a
Other Names
Biochemical cancer inhibit signal transduction H-RasG12V-inhibitor apoptosis antitumor cancer intracellular signaling GTPase enzyme kinase cell growth differentiation mutation human Guanosine-5'-triphosphate binding anchorage-dependent independent SW480 SW 480 K