Purity > 90% as determined by SDS-PAGE. MW: 75.2kDa. Full Length of Mature Protein: 22-555aa. N-terminal 6xHis-SUMO-tagged. Homo sapiens (Human). Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune syst, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the mbrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes.