Periostin (POSTN), also known as OSF-2 (osteoblast specific factor 2), is a 90 kDa secreted matricellular protein originally identified for its high expression in periosteum and periodontal ligament. POSTN contains three domains with distinct functions.? N-terminal cysteine-rich EMI domain binds collagen I, fibronectin, and Notch-1. Four tandem FAS1 domains bind BMP1, tenascin-C, and Integrins. C-terminal domain is a site of proteolytic cleavage and splice variant formation. POSTN interact with extracellular matrix and cell surface receptors enabling it to modulate both biomechanical properties of connective tissues and the cell-matrix interactions. POSTN enhances fibronectin and collagen I production and promotes collagen fibrillogenesis. It enhances cell migration and adhesion through binding integrins. POSTN is frequently overexpressed in various types of human cancers, stimulating metastatic growth by promoting cancer cell survival, invasion and angiogenesis.? POSTN has been shown to be involved in the pathophysiology of several organs. It is induced following myocardial infarction, playing crucial role in collagen fibrilogenesis and cardiac healing. POSTN is also an important mediator and prognostic factor of lung disease.
Size
25 μg
Concentration
n/a
Applications
BA
Other Names
POSTN, PN, Osteoblast Specific Factor 2, OSF2, OSF-2