An inhibitor of HDAC3, HDAC6, and HDAC8 (IC50s = 16.9, 2.47, and 1.46 μM, respectively); selective for HDAC3, 6, and 8 over HDAC1, 2, 7, 9, and 10 (IC50s = >20 μM); inhibits proliferation and colony formation of SMMC-7721 and HepG2 hepatocellular carcinoma cell lines via activation of mitochondrial apoptosis and reduction of c-FLIP,