Calpain 2, (M/II) Large Subunit (CAPN2) (AA 1-700), (Catalytic Subunit) protein (His tag)
Description
Calpain-2 Catalytic Subunit (CANP2) is an intracellular cysteine protease. It contains 1 calpain catalytic domain and 3 EF-hand domains. CANP2 is a member of the peptidase C2 family of intracellular Ca2+-regulated cysteine proteases. These ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits (CANP2) associated with a common small, regulatory subunit (CAPNS1). CANP2 is activated by 200-1000 micromolar concentrations of calcium and inhibited by calpastatin. CANP2 is calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.Alternative Names: Calpain-2 Catalytic Subunit, Calcium-Activated Neutral Proteinase 2, CANP 2, Calpain M-Type, Calpain Large Polypeptide L2, Calpain-2 Large Subunit, Millimolar-Calpain, M-Calpain, CAPN2, CANPL2