A selective antagonist of the activation of VEGFR-3 by VEGF-C (IC50 = 1 μM); does not inhibit ligand-induced autophosphorylation of VEGFR-2, EGFR, IGF-1R, or PDGFRβ; reduces proliferation and induces apoptosis in a variety of cancer cells in vitro and suppresses tumor growth in vivo
Size
5 mg
Concentration
n/a
Applications
n/a
Other Names
biochemical cancer angiogenesis receptor antagonist apoptosis signal transduction protein kinase VEGFR-3 FLT-4 VEGFR3 FLT4 VEGF MAZ-51 signaling VEGF-R3 isoform VEGF-C VEGFC VEGF-D VEGFD lymphatic endothelial cell lymphangiogenesis indoline antagonizes activation VEGFR-2 VEGFR2 autocrine loop induced expression ligand VEGF-A VEGFA reduce proliferation in vitro suppress tumor growth in vivo function survival