[Leu31,Pro34] Neuropeptide Y (human) (trifluoroacetate salt)
Description
A NPY receptor agonist; binds human Y1 and Y5 receptors (Kis = 0.11 and 0.17 nM, respectively); binds rhesus monkey Y1 and Y5 receptors (Kis = 0.08 and 0.18 nM, respectively); reduces forskolin-induced cAMP accumulation in L-M(TK-) cells expressing human and rat Y4 receptors (EC50s = 29.5 and 2.95 nM, respectively); binds to rhesus monkey Y2 and mouse Y6 receptors (Kis = 410 and 9.7 nM, respectively); increases cellular protein mass by 25% in rat ventricular cardiomyocytes (10 nM); increases food intake in rats (0.7-7 nmol, i.c.v.)