Platelet phenotyping by flow cytometry, IF, ELISA, platelet aggregation studies
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Description
Neonatal AlloImmune Thrombocytopenia (NAIT) is the commonest cause of severe isolated thrombocytopenia in the foetus and newborn. In Caucasians, 97% of NAIT are caused by HPA-1a or HPA-5b alloantibodies. By combining CD40 activation and Epstein-Barr virus transformation of B cells isolated from a woman with high titre of anti -HPA-5b alloantibodies. F2H11 human monoclonal antibody is highly specific (does not bind to HPA5a) , and allows a rapid and accurate phenotyping of pregnant women as well as selection of blood donors. (Merieux Y, Rigal D, Pin JJ, XVIIth Regional Congress, International Society of Blood Transfusion, Madrid 2007 ; Guillot-Chene P, Lebecque S, Rigal D, Annales Pharmaceutiques Francaises, 06/2009, 67 (3) 182-6).