Solute Carrier Family 29 Member 3 (SLC29A3) (aa 2-50)
Clone
polyclonal
Host Species
Rabbit
Reactive Species
human
Isotype
n/a
Format
serum
Size
100 μL
Concentration
n/a
Applications
Immunohistochemistry (IHC),Western Blotting (WB)
Reviews / Ratings
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Description
FUNCTION: Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). Mediates transport of adenine, adenosine and uridine, as well as several nucleoside analog drugs, such as anticancer and antiviral agents, including cladribine, cordycepin, tubercidin and AZT. Does not transport hypoxanthine. Defects in SLC29A3 are the cause of histiocytosis-lymphadenopathy plus syndrome (HLAS). SUBCELLULAR LOCATION: Membrane, Multi-pass membrane protein. Late endosome membrane. Lysosome membrane. Note: Observed in a punctate intracellular pattern showing partial colocalization with late endosomes/lysosomes. Not detected at the cell surface. Tissue specificity: Widely expressed in both adult and fetal tissues. Highest levels in placenta, uterus, ovary, spleen, lymph node and bone marrow. Lowest levels in brain and heart. Synonyms: Equilibrative nucleoside transporter 3, Solute carrier family 29 member 3, ENT3
Immunogen
A synthetic peptide from aa region 2-50 of human SLC29A3 conjugated to an immunogenic carrier protein was used as the antigen.