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Description
Rabbit IgG polyclonal Picoband? antibody for Caveolin-3/CAV3 detection. Tested with WB, IHC-P, IHC-F, IF, Direct ELISA in Human;Mouse;Rat. No cross reactivity with other proteins. Caveolin-3 is a protein that in humans is encoded by the CAV3 gene. This gene encodes a caveolin family member, which functions as a component of the caveolae plasma membranes found in most cell types. Caveolin proteins are proposed to be scaffolding proteins for organizing and concentrating certain caveolin-interacting molecules. Mutations identified in this gene lead to interference with protein oligomerization or intra-cellular routing, disrupting caveolae formation and resulting in Limb-Girdle muscular dystrophy type-1C (LGMD-1C), hyperCKemia or rippling muscle disease (RMD). Alternative splicing has been identified for this locus, with inclusion or exclusion of a differentially spliced intron. In addition, transcripts utilize multiple polyA sites and contain two potential translation initiation sites.
Immunogen
E.coli-derived human Caveolin-3/CAV3 recombinant protein (Position: M1-D55).