1633-1769aa; Partial. MW: 18.77kD. Purity >90% as determined by SDS-PAGE. The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.
Molecular characterization of the tight junction protein ZO-1 in MDCK cells.Gonzalez-Mariscal L., Islas S., Contreras R.G., Garcia-Villegas M.R., Betanzos A., Vega J., Diaz-Quinonez A., Martin-Orozco N., Ortiz-Navarrete V., Cereijido M., Valdes J.Exp. Cell Res. 248:97-109(1999) The heat-shock protein Apg-2 binds to the tight junction protein ZO-1 and regulates transcriptional activity of ZONAB.Tsapara A., Matter K., Balda M.S.Mol. Biol. Cell 17:1322-1330(2006)