Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Participates in cardiomyo
Size
100 assays
Concentration
n/a
Applications
This ELISA kit is used for quantitative measurement of PIK3CA in human serum, plasma, tissue homogenates and other biological fluids.