1-230aa; Full Length. MW: 52.1kD. Purity >90% as determined by SDS-PAGE. Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity toward KCNMA1. Has low lysophospholipase activity.
Cloning, expression, and catalytic mechanism of murine lysophospholipase I.Wang A., Deems R.A., Dennis E.A.J. Biol. Chem. 272:12723-12729(1997) Lubec G., Yang J.W., Zigmond M.Submitted (JUL-2007) to UniProtKBRegiospecificity and catalytic triad of lysophospholipase I.Wang A., Loo R., Chen Z., Dennis E.A.J. Biol. Chem. 272:22030-22036(1997) Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.Rardin M.J., Newman J.C., Held