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Description
Polyclonal Antibody to detect Cyclin F in human, mouse and rat samples. Cyclin F is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is ubiquitously expressed in human cells but fluctuates dramatically through the cell cycle, peaking in G2 like cyclin A and decreasing prior to decline of cyclin B. Cyclin F exhibits regulated subcellular localization, being localized in the nucleus in most cells, with a significant percentage of cells showing only perinuclear staining.
Immunogen
This Cyclin F antibody is generated from KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Cyclin F. The exact sequence is proprietary.
Other Names
F-box only protein 1, CCNF, FBX1, FBXO1, G2/mitotic-specific cyclin-F