Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 2 (SLC2A2) (N-Term)
Clone
polyclonal
Host Species
Rabbit
Reactive Species
mouse
Isotype
n/a
Format
serum
Size
100 μL
Concentration
n/a
Applications
Immunohistochemistry (IHC),Western Blotting (WB)
Reviews / Ratings
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Description
FUNCTION: Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells, may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na+/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney. Defects in SLC2A2 are the cause of Fanconi-Bickel syndrome (FBS). FBS is a rare, well-defined clinical entity, inherited in an autosomal recessive mode and characterized by hepatorenal glycogen accumulation, proximal renal tubular dysfunction, and impaired utilization of glucose and galactose. SUBCELLULAR LOCATION: Membrane, Multi-pass membrane protein. TISSUE SPECIFICITY: Liver, insulin-producing beta cell, small intestine and kidney. In embryo, expressed in endoderm layer of yolk sac and liver primordium. Synonyms: Solute carrier family 2, facilitated glucose transporter member 2, GLUT-2, SLC2A2, GLUT2
Immunogen
A synthetic peptide from n-terminal region of mouse SLC2A2 conjugated to an immunogenic carrier protein was used as the antigen.