Recombinant Human Transcriptional enhancer factor TEF-1 (TEAD1)
Description
Purity > 90% as determined by SDS-PAGE. MW: 49.9kDa. Full Length: 1-426aa. N-terminal 6xHis-tagged. Homo sapiens (Human). Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (T) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.
Size
100ug
Concentration
n/a
Applications
RUO
Other Names
NTEF-1; Protein GT-IICTEA domain family member 1; TEAD-1Transcription factor 13; TCF-13