Solute Carrier Family 1 (Glial High Affinity Glutamate Transporter), Member 2 (SLC1A2) (aa 500-550)
Clone
polyclonal
Host Species
Rabbit
Reactive Species
rat, mouse, human
Isotype
n/a
Format
unconjugated
Size
500 μg
Concentration
n/a
Applications
Immunohistochemistry (IHC),Western Blotting (WB)
Reviews / Ratings
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Description
Mediates dihydrokainate-sensitive glutamate transport, may play a role in presynaptic terminal glutamate transport and synaptic transmission.Function: Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.Subunit: Homotrimer. Interacts with JUB.Subcellular location: Membrane, Multi-pass membrane protein.Tissue specificity: Localized in brain and is highly enriched in the Purkinje cell layer in cerebellum, retina. Also known as: Sodium-dependent glutamate/aspartate transporter 2, GLUT-R, GLT-1, Solute carrier family 1 member 2, Slc1a2, Eaat2, Glt1.
Immunogen
A synthetic peptide from aa region 500-550 of rat SLC1A2 conjugated to an immunogenic carrier protein was used as the antigen. The antigen shares 95% identity with human and mouse sequence.