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Description
VEGF Receptor 1 Monoclonal Antibody (3D10). This gene encodes a member of the vascular endothelial growth factor receptor family. VEGFR family members are receptor tyrosine kinases which contain an extracellular ligand-binding region with seven immunoglobulin domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The solubl