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Description
VHL Polyclonal Antibody. Von Hippel-Lindau syndrome is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor , which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding
Immunogen
n/a
Other Names
VHL; von Hippel-Lindau tumor suppressor; HRCA1; RCA1; VHL1 ; elongin binding protein; von Hippel-Lindau syndrome