Immunohistochemistry (Paraffin): 1:50-1:100, Western Blot: 2 μg/mL
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Description
Villin Monoclonal Antibody (CWWB1). Villin can cap, nucleate, sever and bundle actin in a Ca and phosphoinositide-regulated manner. It is associated with the microvillar actin core bundle of intestinal and renal brush border implicated in adsorption. Villin is composed of six repeats, each containing 150 residues that together constitute the core domain followed by the carboxyl-terminal headpiece domain of 87 residues. The core domain retains the Ca dependent capping nucleating and severing activity, whereas the headpiece domain contributes towards actin filament bundling and binding F-actin, independently of Ca