Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:500-1:2000
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Description
PIGR Polyclonal Antibody. Polymeric IgA and IgM is produced and secreted by B cells in the lamina propria, which is beneath the mucosal lining of polarized epithelial cells. Polymeric immunoglobulin receptors, also designated pIgRs, are expressed on the basolateral surface of glandular epithelia and mediate transcellular transport of secretory immunoglobulin polymers across the epithelium. pIgR associates with secreted dimeric IgA and IgM molecules. During transcellular transport of these Ig polymers, pIgR undergoes proteolytic cleavage to generate a fragment called secretory component (SC), polymeric immunoglobulin receptor or poly-IG receptor. When immunoglobulin polymers associate with SC, they become resistant to enzymatic degradation d
Immunogen
n/a
Other Names
Hepatocellular carcinoma associated protein TB6; Hepatocellular carcinoma-associated protein TB6; Phosphatidylinositol glycan, class R; PIGR; PIGR_HUMAN; Poly Ig receptor; Poly-Ig receptor; Polymeric immunoglobulin receptor; Secretory component; Transmembrane secretory component;