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Description
SKP2 Polyclonal Antibody. Skp2 (S-phase Kinase-associated Protein 2) belongs to the family of F-box proteins that interact with the Cyclin A-Cdk2 complex. Skp2 is essential for the G1-S transition in both transformed cells and diploid fibroblasts. Biochemical and genetic experiments have demonstrated that Skp2 is required for the ubiquitination and consequent degradation of p27 in cultured mammalian cells and in vitro reconstitution assays. In normal tissues, Skp2 is expressed in tonsil and placenta. In tumor tissues, Skp2 is expressed widely, in some colon, prostate, pancreas, and skin cancers, with high expression in lung, breast, ovarian, and endometrial cancers. Research suggests that Skp2 plays a role in oncogenesis, particularly in th
Immunogen
n/a
Other Names
CDK2/cyclin A-associated protein p45; F-box protein Skp2; F-box/LRR-repeat protein 1; OTTHUMP00000221389; S-phase kinase-associated protein 2; cyclin A/CDK2-associated protein p45; cyclin-A/CDK2-associated protein p45; p45skp2