655-1213. Partial. MW: 80.33kD. Purity >90% as determined by SDS-PAGE. Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens.
Primary structure of the mannose receptor contains multiple motifs resembling carbohydrate-recognition domains.Taylor M.E., Conary J.T., Lennartz M.R., Stahl P.D., Drickamer K.J. Biol. Chem. 265:12156-12162(1990) Molecular characterization of the human macrophage mannose receptordemonstration of multiple carbohydrate recognition-like domains and phagocytosis of yeasts in Cos-1 cells.Ezekowitz R.A., Sastry K., Bailly P., Warner A.J. Exp. Med. 172:1785-1794(1990) Organization of the gene encoding