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Description
The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction,inflammation,growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I,vascular anticoagulant-alpha,endonexin II,lipocortin V,placental protein 4 and anchorin CII. The gene spans 29 kb containing 13 exons,and encodes a single transcript of approximately 1. 6 kb and a protein product with a molecular weight of about 35 kDa. [provided by RefSeq,Jul 2008]This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex,which is involved in the blood coagulation cascade. Subunit structure: Monomer. Binds ATRX and EIF5B By similarity. Interacts with hepatitis B virus (HBV). Sequence similarities: Belongs to the annexin family. Contains 4 annexin repeats.
Immunogen
Purified recombinant human Annexin V protein fragments expressed in E.coli.