CHRNA6, 26-239aa, Human, His tag, E.coli (Denatured)
Description
Purity: > 85% by SDS - PAGE Format: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol . Cholinergic receptor, nicotinic, alpha 6, also known as CHRNA6, belongs to the nicotinic acetylcholine receptors (nAChRs) family. nAChRs are heteropentameric ligand-gated ion channels resulting from the assembly of alpha and beta protein subunits. This ion channel is gated by the binding of acetylcholine to the assembled receptor. Alpha 6 is often found associated with beta 3, beta 2, and alpha 4 subunits. CHRNA6 receptors have a relatively selective localization to the nigrostriatal pathway where they function to mediate dopamine release. Recombinant human CHRNA6 protein, fused to His-tag at N-terminus, was expressed in E.coli.