MW: 39,774 Da. Purity >90%, as determined by SDS-PAGE and HPLC. IL-10 is produced by mouse Th2-cells following their stimulation by lectins. The main source for B-cell derived IL10 in mice are Ly1 B-cells that express CD5 (Ly1) and CD11.In humans IL10 is produced by activated CD8 (+) peripheral blood T-cells, by T-helper CD4 (+) T-cell clones after both antigen-specific and polyclonal activation, by B- cell lymphomas, and by monocytes following cell activation by bacterial lipopolysaccharides an
? genetic variation in the il-10 pathway modulates severity of acute graft-versus-host disease following hematopoietic cell transplantation: synergism between il-10 genotype of patient and IL-10 receptor genotype of donor .Blood, Dec 2005; 106: 3995 - 4001. ? association of il-10 and IL-10 receptor gene polymorphisms and graft-versus-host disease following hematopoietic cell transplantation. .Blood (ASH Annual Meeting Abstracts), Nov 2004; 104: 421. ? the expanded family of class