Purity >97%, as determined by SDS-PAGE and HPLC. The effects of IL-6 are mediated by a functional IL- 6 receptor (IL-6R), which consists in a heterodimer formed by an IL-6-binding α chain (IL-6Rα) and a signal- transducing subunit, gp130 or IL-6Rβ. Binding of IL-6 to the IL-6Rα induces homodimerization of two gp130 molecules, leading to intracellular signals.
? anti-inflammatory effect of IL-6 receptor blockade on experimental corneal alkali burn .Invest. Ophthalmol. Vis. Sci., Mar 2012; 53: 4206. ? exposure-response relationship of tocilizumab, an anti-IL-6 receptor monoclonal antibody, in a large population of patients with rheumatoid arthritis .J. Clin. Pharmacol., Feb 2012; 10.1177/0091270012437585. ? impact of IL-6 receptor inhibition on human memory b cells in vivo: impaired somatic hypermutation in preswitch memory b cells and m