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Description
THOC1 is a component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between THOC4 and the cap-binding protein NCBP1. UAP56 functions as a bridge between THOC4 and the THO complex. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Synonyms: Monoclonal THOC1 antibody, Anti-THOC1 antibody, THO complex 1 antibody, P84 antibody, HPR1 antibody, P84N5 antibody.
Immunogen
THOC1 antibody was raised in mouse using recombinant Human Tho Complex 1